Several published studies have found that the use of aspirin, if chewed, can contribute to the cause of tooth erosion. These studies analyzed both laboratory studies, where extracted teeth were placed in a water and aspirin mixture, and clinical case studies of people who took six doses of aspirin powder per day for a two-to-three year period. In the laboratory study, scientists observed changes in the surface of both the enamel, outer covering of the teeth, and dentin, the layer of tooth structure under the enamel, of the extracted teeth tested. In the clinical case study, the top surface of the teeth, also called the occlusal surface, showed severe erosion of the lower molars and premolars and on the lower anterior teeth on the tongue side. The researchers concluded that the aspirin powder caused the tooth erosion.
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Study: A Daily Baby Aspirin Has No Benefit For Healthy Older People
Risks From Daily Low-Dose Aspirin Outweigh Benefits For Healthy Seniors : Shots - Health News : NPR
The use of aspirin for primary prevention of cardiovascular disease CVD in patients with diabetes mellitus DM is associated with lower rates of cardiovascular events but increased risks of bleeding complications. A life-long Markov model was developed to compare aspirin therapy mg daily versus no use of aspirin in DM patients with no history of CVD. Model validation was conducted by comparing the simulated event rates with data reported in a clinical trial. Direct medical costs and quality-adjusted life-years gained QALYs were the primary outcomes from the perspective of healthcare system in China. Sensitivity analyses were performed to examine the uncertainty of model inputs. The base-case results were sensitive to the odds ratio of all-cause death in aspirin therapy versus no use of aspirin.
CASE STUDY (Peptic Ulcer)
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Many drugs, when taken in overdose, can deleteriously affect acid-base balance, leading to abnormal arterial blood gas ABG results. Aspirin is one such, and perhaps because of its easy availability, one of the most common of all drugs to be taken in overdose. Salicylate aspirin poisoning thus represents the most common of drug-related acid-base disturbances. A recently published paper describes an unusually severe case of salicylate poisoning that reminds us that aspirin overdose can, unfortunately but rarely, have a fatal outcome.