While studying Yersinia pestis , the bacteria responsible for epidemics of plague such as the Black Death, Wyndham Lathem, Ph. They further showed how later modifications of this gene enhanced infections associated with the bubonic plague. This research helps us better understand how bacteria can adapt to new host environments to cause disease by acquiring small bits of DNA," Lathem said. The team examined ancestral strains of the bacteria in mouse models to learn when Y. In the most ancestral of all currently existing Y.
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PLoS Med 5 1 : e3. This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The organizations played no further role, including no role in the submission of this article. HL declares that he participated in the same project and that he is holding a research grant from the Fund for Scientific Research Flanders to investigate the distribution of plague in Africa.
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The successful reconstruction of an ancient bacterial genome from archaeological material presents an important methodological advancement for infectious disease research. The reliability of evolutionary histories inferred by the incorporation of ancient data, however, are highly contingent upon the level of genetic diversity represented in modern genomic sequences that are publicly accessible, and the paucity of available complete genomes restricts the level of phylogenetic resolution that can be obtained. Here we add to our original analysis of the Yersinia pestis strain implicated in the Black Death by consolidating our dataset for 18 modern genomes with single nucleotide polymorphism SNP data for an additional strains at over positions. The inclusion of this additional data reveals a cluster of Y.
The Bubonic Plague The plague was caused by a bacterial infection carried by the fleas of rodents. When the fleas come into contact with humans the outcome can be devastating and horrifying. The Bubonic plague, also known as The Black Death, is one of the most well-known plagues in history.