Endometriosis, PCOS, and unexplained infertility are currently the most common diseases rendering large numbers of women infertile worldwide. Oxidative stress, due to its deleterious effects on proteins and nucleic acids, is postulated to be the one of the important mechanistic pathways in differential expression of proteins and in these diseases. The emerging field of proteomics has allowed identification of proteins involved in cell cycle, as antioxidants, extracellular matrix ECM , cytoskeleton, and their linkage to oxidative stress in female infertility related diseases. The aim of this paper is to assess the association of oxidative stress and protein expression in the reproductive microenvironments such as endometrial fluid, peritoneal fluid, and follicular fluid, as well as reproductive tissues and serum. The review also highlights the literature that proposes the use of the fertility related proteins as potential biomarkers for noninvasive and early diagnosis of the aforementioned diseases rather than utilizing the more invasive methods used currently.
Infertility Research Papers
The findings suggest that these genes may play a far more complex role in oocyte maturation than previously assumed. For viable oocyte maturation and generation of new life, bidirectional communication, i. Prior to ovulation, an oocyte resides in a follicle, which is a small fluid-filled sac that ruptures at ovulation, releasing the oocyte into the oviduct. For oocyte maturation and its release from the follicle, the oocyte as well as the follicle cells surrounding it, i. These granulosa cells also produce hormones that are essential for successful adherence of the embryo to the wall of the uterus and the survival of early pregnancy.
Infertility Research Paper
Correspondence Address : Dr. There is thus the need to find the causes of infertility in context to local population to aid and direct management strategies accordingly. Aims: The aims were to study the causes of infertility and to calculate the proportion of the individual factors contributing to it in the population coming to a tertiary level public health facility.
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